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New microchip could enable scientists to grow sperm in laboratory

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Israeli researchers have finally developed a silicone microchip that helps grow human sperm in the laboratory.

This technique has been successfully tested in mice and may eventually prove to be effective in solving the problem of male infertility.

The team at Negev Ben Gurion University, in collaboration with a research group at Technion-Israel Institute of Technology, may in the future collect tissue from boys with cancer who have received aggressive chemotherapy or from certain infertile men. It states that it is, and is used to produce sperm.

The team has already developed a procedure in the laboratory to create sperm cells from immature mice and is currently preparing to apply the experiment to the next stage, human cells.

Mouse sperm are grown using a microfluidic system containing microchips made from PDMS (polydimethylsiloxane) specifically adapted for study.

“This study opens up new horizons in the process of producing sperm cells in culture,” said Professor Mahmood Freihel of the University’s Faculty of Health Sciences, Schlaga Seagull Microbiology, Immunology and Genetics.

“It is a microfluid in future treatment strategies for infertile men in maintaining fertility in children undergoing aggressive chemotherapy / radiation therapy that can impair adolescent fertility. Allows implementation of the base technology.

“In addition, this system could also serve as an innovative platform for investigating the effects of drugs and toxins on male fertility.”

Mice too young to produce sperm were a model that allowed the team to simulate the natural environment for sperm cell growth in the testis.

They have built a complete system that includes canals that allow the addition of growing cells, cells from the testicles, or other cells from body tissues.

Cultures were tested after 5-7 weeks and showed a semen tube-like structure containing cells at an advanced stage during spermatogenesis.

Professor Huleihel said he must be confident that spermatogenesis avoids the risk of returning cancer cells to the patient’s body.

This study was recently published in a peer-reviewed journal Biofabrication.

The research group included Professor Emeritus Eitan Lunenfeld of the University of Ben Gurion University of Health Sciences, Soroka Medical Center, now a senior faculty member at Ariel University, and Professor Gilad Yossifon of the Faculty of Mechanical Engineering. At Technion (currently a faculty member of the Faculty of Mechanical Engineering at Tel Aviv University).

The study was led by Ali Abmadigem, a PhD student in the Department of Microbiology, Immunology and Genetics at the University of Negev Ben Gurion, and Sholomschchat at the Department of Mechanical Engineering at Technion-Israel Institute of Technology.

This study was supported by the Israeli Science Foundation (ISF) and was conducted in collaboration with the China Natural Sciences Foundation (NSFC), the Fertilizer Center of the Faculty of Health Sciences, Negeb Ben Gurion University, and the Council for Higher Education Scholarships. For excellent PhD students of ultra-Orthodox and Arabs.

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